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As an innovative cell therapy to combat cancers, the chimeric antigen receptor (CAR) T immunotherapy can engineer the patient’s immune cells by utilizing CAR T cells. The immunotherapy also entails some technologies including the CAR T library technology and the CellRapeutics™ TCR technology. This article is about to introduce the CAR T immunotherapy and these technologies.


CAR T Immunotherapy


Conventional approaches to cancer treatment, such as invasive surgeries, radiation and the chemotherapy, are not quite effective and even worse Cheap Nashville Predators Jerseys , can easily do much damage to human health. On the other hand, the CAR T immunotherapy is more specific to the disease treatment while less toxic to the patient’s body. Furthermore, the treatment process is simple. By adding an artificial receptor to the surface of the cells extracted from the patient’s blood, doctors infuse the cells back into the patient’s body and then begins the process of proliferating and attacking against tumor cells. Recently, the T cell immunotherapy was used for clinical trials to conquer cancers. So far Wholesale Predators Jerseys , the new immunotherapy has proven to be quite effective in eradicating numerous tumors, particularly for B cell malignancies, with up to 95% response rates and durable complete remission.


CAR T library technology


The CAR T library technology is significant for the CAR T immunotherapy. With this cutting-edge technology, the CAR T libraries with a capacity of around 108 can be established by constructing CAR genes with diverse antibody fragments (e.g. scFv, Fab Cheap Predators Jerseys , scFab) against a certain target into vectors. These antibodies will be displayed on the surface of the T lymphocytes, which can be screened thereafter. Since the T cell activation is linked with the expression and function of the CARs, functional CARs with high affinities ranging from 10 pmol to nmol can be obtained for sure. Soon the stable clones will be applied to clinical trials. Thus far, CAR-T libraries have been produced, not only for the blood cancer antigen CD19 Juuse Saros Predators Jersey , but also for solid tumors against different antigens, such as Her2, EGFR, VEGFR.


CellRapeutics™ TCR Technology


In order for human immunity to be strengthened, the T cell development is critical Roman Josi Predators Jersey , especially for its receptors, which leads to the T cell receptor (TCR) technology. The technology aims to optimize the expression and function of the TCR through genetic engineering. The core notion of this technology is that the TCR will interact with an antigen on a target cell when the appropriate major histocompatibility complex presents the target peptide sequence. In practice, there are two phases for carrying out the technology. First, isolating the TCR that recognizes the peptides presented by MHC class I molecules on the surface of cancer cells. Second, modifying and introducing the isolated TCR into T cells Ryan Hartman Predators Jersey , thus redirecting it to kill the tumor cells that express the targets of interest.


The CAR T immunotherapy needs supports from technologies such as the CAR T library technology and the TCR technology. The advancement in technology will surely promote the development of medical therapies. In the future, more advanced technologies are going to come out to support the immunotherapy for cancer treatment.


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